Neurons excitability changes in rat medial vestibular nucleus following vestibular neurectomy
Intrinsic excitabilities of acutely isolated medial vestibular nucleus (MVN) neurons of rats with normal labyrinth and with undergoingvestibular compensation from 30 min to 24 h after unilateral vestibular deafferentation (UVD) were compared. In control rats, proportions of type A andB cells were 30 and 70%, respectively, however, the proportion of type A cells increased following UVD. Bursting discharge and irregular firingpatterns were recorded from 2 to 12 h post UVD. The spontaneous discharge rate of neurons in the ipsilesional MVN increased significantly at 2 hpost-UVD and remained high until 12 h post-UVD in both type A and type B cells. Mter-hyperpolarization (AHP) of the MVN neurons decreasedsignificantly from 2 h post-UVD in both types of cells. These results suggest that the early stage of vestibular compensation after peripheralneurectomy is associated with an increase in intrinsic excitability due to reduction of AHP in MVN neurons.
作 者： 金麟毅 Linyi Jin 作者单位： 吉林医药学院基础部,吉林,吉林,132000 刊 名： 科技信息 英文刊名： SCIENCE & TECHNOLOGY INFORMATION 年，卷(期)： 2008 ""(22) 分类号： Q42 关键词： vestibular compensation 前庭修复 MVN中央前庭核 rat 大白鼠