Synthesis and Biological Evaluation of Novel N-Benzoxazolonyluracils as Protox-Inhibitor
Protoporphyrinogen oxidase inhibitor has become the focus research field as herbicides.Seven novel N-benzoxazolonyluracils were obtained by cyclization of 6-aminobenzoxazolone derivatives with ethyl 3-dimethylcarbamoylamido-4,4,4-trifluorocrotonate and then methylation or amination, and the reaction yields were between 590%-860%. The chemical structures of the compounds were identified by Elemental Analysis, MS and 1H NMR. Biological results indicate that some compounds exhibit excellent control of broadleaf weeds at post-emergence by low dosage 18.75 ga.i/ha, but are not effective for grass weeds below dosage 37.5 ga.i/ha. In addition, these compounds show no damage at high-dosage 150 ga.i/ha to wheat and corn, but are unsafe to dicotyledonous plants such as cole, soybean and sorghum even at lower dosage 18.75 ga.i/ha.
作 者： HOU Zhongke Ren Yeguo LEI Manxiang Huang Mingzhi SONG Jian Chen Ligong 作者单位： HOU Zhongke(School of Pharmaceutical and Technology, Tianjin University, Tianjin 300072, China;Hunan Research Institute of Chemical Industry, Changsha 410007, China)Ren Yeguo,LEI Manxiang,Huang Mingzhi(Hunan Research Institute of Chemical Industry, Changsha 410007, China)
SONG Jian,Chen Ligong(School of Pharmaceutical and Technology, Tianjin University, Tianjin 300072, China)
刊 名： 天津大学学报(英文版) EI 英文刊名： TRANSACTIONS OF TIANJIN UNIVERSITY 年，卷(期)： 2005 11(1) 分类号： Q5 关键词： N-benzoxazolonyluracil protox-inhibitor synthesis biological evaluation