Synthesis and Preliminary Anti-leukemia Activity of N-(Substituted Benzyl)-4-hydroxy-4-substituted Piperidine Derivative
In order to find some lead compounds with high inhibition against leukemia, twelve unreported compounds 6a-61 have been synthesized with substituted benzylamines as raw materials via a series of Michael addition, Dieckmann condensation, hydrolysis decarboxylation and reactions with Grignard reagent. Complete assignments have been achieved for the title compounds by 1H NMR, IR, MS and elemental analysis. The preliminary anti-tumor activity tests indicate that the title compounds have good effect on the cellular growth inhibition against K562 cells and have potential anti-leukemia bioactivity.
作 者： FANG Zhikun XUE Sijia CHEN Long XU Yang YIN Anqin LI Chunyan 作者单位： Department of Chemistry,College of Life and Environmental Science,Shanghai Normal University,Shanghai 200234,China 刊 名： 中国化学（英文版） SCI 英文刊名： CHINESE JOURNAL OF CHEMISTRY 年，卷(期)： 2009 27(2) 分类号： O6 关键词： piperidine derivative synthesis inhibition K562 MTT