Two Series of Synthetic Territrem B Analogues and their Biological Activities
Two series of territrem B analogues (6, 11) were designed and synthesized from jujubogenin 2. Compound 11c inhibited AChE with the ratio of 70% at 10-4 mol/L. Compounds5a, 5b, 6a and 11b showed moderate cytotoxicity on cultured KB cells at 10-6 mol/L.Compounds 5c and 6b alleviated injury arising from oxygen-glucose deprivation (OGD).
作 者： Feng ZHAO Jin Hao ZHAO Hai Bo LI Lei Xiang YANG Hua Bai Yan Guang WANG Shoei Sheng LEE Yu ZHAO 作者单位： Feng ZHAO,Hai Bo LI,Lei Xiang YANG,Yu ZHAO(Department of Traditional Chinese Medicine and Natural Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310031)Jin Hao ZHAO(Department of Traditional Chinese Medicine and Natural Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310031;Department of Chemistry, College of Sciences, Zhejiang University, Hangzhou 310027)
Hua Bai(Zhejiang Hisun Naturelite Pharmaceutical R&D Co., Ltd., Hangzhou 310007)
Yan Guang WANG(Department of Chemistry, College of Sciences, Zhejiang University, Hangzhou 310027)
Shoei Sheng LEE(Department of Pharmacy, College of Medicine, National Taiwan University, Taipei 10018)
刊 名： 中国化学快报（英文版） ISTIC SCI 英文刊名： CHINESE CHEMICAL LETTERS 年，卷(期)： 2005 16(4) 分类号： 关键词： Territrem B analogues acetylcholinesterase (AChE) inhibitor cytotoxicity on KB cells oxygen-glucose deprivation (OGD)