Isolation and pharmacological activities of bromophenols from Rhodomela confervoides
Four bromophenols were isolated from the extract of marine red alga, Rhodomela confervoides by column chromatography and HPLC methods. By means of spectroscopic methods including IR, MS, 1D, and 2D-NMR techniques, their structures were elucidated as (1) 3-bromo-4,5-dihydroxy benzoic acid methyl ester; (2) bis (2,3-dibromo-4,5-dihydroxybenzyl) ether; (3) 3,4-dibromo-5-(methoxymethyl)-1,2-benzenediol and (4) 3-bromo-4,5-dihydroxy-benzaldehyde. Compound 1 was first isolated from the algae in nature, and 1, 4 were found to have selective cytotoxic activities against KB, Bel 7402 and A549 cells, 2 showed powerful antibacterial activities against Staphylococcus aurens and Pseudomonas aeruginosa.
作 者： Han Lijun XU Nianjun SHI Jiangong Yan Xiaojun Zeng Chengkui 作者单位： Han Lijun,XU Nianjun,Zeng Chengkui(Institute of Oceanology,Chinese Academy of Sciences,Qingdao 266071,China)SHI Jiangong(Institute of Marina Medica,ChineseAcademy of Medical Sciences,Beijing 100050,China)
Yan Xiaojun(Key Laboratory of Marine Biotechnology,Ningbo University,Ningbo 315211,China)
刊 名： 中国海洋湖沼学报（英文版） ISTIC SCI 英文刊名： CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY 年，卷(期)： 2005 23(2) 分类号： 关键词： Rhodomela confervoides bromophenol antitumor antibacterial