Protective Effect of Topically Applied Polypeptide from Chlamys farreri Against Ultraviolet Radiation-Induced Chronic Sk
Polypeptide from Chlamys farreri (PCF) , a topical polypeptide isolated from Chlamys farreri, was used in this experiment aimed to investigate the photoprotective effect of PCF against chronic skin damage induced by ultraviolet A (UVA) and ultraviolet B (UVB) radiation. The chronic ultraviolet-irradiated guinea pig model was established, and visible changes in the skin including wrinkling, sagging and erythema were observed. Malondialdehyde (MDA) and antioxidant enzymes including superoxide dismutase (SOD) and glutathione peroxidase (GSH-px) in the dorsal skin were determined using biochemical methods. The results showed:(1)PCF (5 % and 20%) could greatly protect the dorsal skin of guinea pig against wrinkling, sagging and erythema induced by UV radiation in a concentration-dependent manner.(2)PCF could reduce MDA formation in the dorsal skin caused by UV irradiation, while increasing the activities of SOD and GSH-px.(3)The differences among the PCF groups and UV model group were significant (P＜0.05, P＜0.01). These results indicated that topical application of PCF provided broad solar UV spectrum photoprotection; and that the antioxidant property of PCF might play a role in photoprotection.
作 者： 迟明亮 曹鹏利 于国英 朱莉 王跃军 王春波 作者单位： Medical College, Qingdao University, Qingdao 266021, China 刊 名： 中国海洋湖沼学报(英文版) ISTIC SCI 英文刊名： CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY 年，卷(期)： 2003 21(4) 分类号： P7 关键词： polypeptide from Chlamys farreri ultraviolet radiation photoprotection antioxidant guinea pig