Stable RNA hairpins in 88 coding regions of human mRNA
RNA hairpins containing UNCG, GNRA, CUUG (N=A, U, C or G, R＝G or A) loops are unusually thermodynamic stable and conserved structures. The structural features of these hairpin loops are very special, and they play very important roles in vivo. They are prevalent in rRNA, catalytic RNA and non-coding mRNA. However, the 5′ C(UUCG)G 3′ hairpin is not found in the folding structure of 88 human mRNA coding regions. It is also different from rRNA in that there is no preference for certain sequences among tetraloops in these 88 mRNA folding structures.
作 者： PAN Min Wang Chuanming LIU Ciquan 作者单位： PAN Min,Wang Chuanming(Modern Biological Center, Yunnan University, Kunming 650091, China)LIU Ciquan(Modern Biological Center, Yunnan University, Kunming 650091, China;Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China;Center for Theoretical Biology, Peking University, Beijing 100871, China)
刊 名： 自然科学进展(英文版) SCI 英文刊名： PROGRESS IN NATURAL SCIENCE 年，卷(期)： 2004 14(11) 分类号： Q3 关键词： thermodynamic stability hairpin UNCG GNRA RNA structure