Improved Preparation of Tyramine by Curtius Rearrangement
An improved and facile preparation of tyramine [2-(p-hydroxyphenyl)ethylamine] was described, which starts from phenol and acrylonitrile to form β-(p-hydroxyphenyl) propionic acid via Friedel-Craft's alkylation and nitrile hydrolysis. After hydrazinolysis and a subsequent Curtius rearrangement, tyramine was obtained in 30.2% total yield.
作 者： LI Yun YANG Fan XU Xiaoying PAN Shiyin WANG Lixin XIA Chuanqin 作者单位： LI Yun,YANG Fan,XIA Chuanqin(Department of Chemistry,Sichuan University,Chengdu,Sichuan 610041,China)XU Xiaoying,PAN Shiyin,WANG Lixin(Key Laboratory of Asymmetric Synthesis & Chirotechnology of Sichuan Province and National Engineering Research Center of Chiral Drugs,Chengdu Institute of Organic Chemistry,Chinese Academy of Sciences,Chengdu,Sichuan 610041,China)
刊 名： 中国化学（英文版） SCI 英文刊名： CHINESE JOURNAL OF CHEMISTRY 年，卷(期)： 2009 27(2) 分类号： O6 关键词： preparation tyramine β-(p-hydroxyphenyl)propionic acid curtius rearrangement