Syntheses of Nucleoside Derivatives

Syntheses of Nucleoside Derivatives Containing Fmoc- or Trityl-protected Amino Acids

Facile direct esterification reactions between 2′,3′-O-isopropylidene-nucleosides and Fmoc- or trityl-protected amino acids via N,N-dicyclohexyl-carbodiimide(DCC) mediated condensation are described. These reactions offer a mild and convenient method to synthesize aminoacylated nucleoside derivatives.

作 者： GUO Hui ZOU Wu-xin JI Qi MA Yu-xin MENG Ji-Ben   作者单位： Department of Chemistry, Nankai University, Tianjin 300071, P. R. China  刊 名： 高等学校化学研究（英文版）  ISTIC SCI 英文刊名： CHEMICAL RESEARCH IN CHINESE UNIVERSITIES  年，卷(期)： 2005 21(4)  分类号： O6  关键词： Nucleoside   Amino acid   Esterification   2′   3′-O-Isopropylidene-nucleoside  

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