Morphological and electrophysiological evidence for regeneration of transected spinal cord fibers and restoration of mot
After 2/3 transection of the right ninth thoracic spinal cord of an adult rat, a chitosan tube seeded with L-poly-lysine was implanted between the rostral and caudal end of the lesioned cord. Twelve months after the operation, regeneration of myelinated and non-myelinated axons and new blood vessels were observed along the wall of the chitosan tube implanted under an electron microscope. Somatosensory evoked potentials (SEP) could be consistently recorded from the left somatosensory cortex following electrical stimulation of the right hind limb, while transcranial magnetic stimulation of the left motor cortex could also evoke motor activity from the right hind limb. The present result suggests that implanted chitosan tube might be useful in regeneration of injured nerve fibers of the spinal cord resulting in a long-term restoration of motor functions.
作 者： LI Xiaoguang YANG Zhaoyang YANG Yi 作者单位： LI Xiaoguang,YANG Zhaoyang(Beijing Center for Neural Regeneration and Repairing, Capital University of Medical Sciences, Beijing 100054, China;Department of Bioengineering, Beijing University of Aeronautics & Astronautics, Beijing 100083, China)YANG Yi(National Center of Biomedical Analysis, Beijing 100850, China)
刊 名： 科学通报（英文版） SCI 英文刊名： CHINESE SCIENCE BULLETIN 年，卷(期)： 2006 51(8) 分类号： O4 关键词： spinal cord injury CNS regeneration chitosan tube electron microscope somatosensory evoked potentials motor activity transcranial magnetic stimulator