Alpha -tocopherol supplementation on chromium toxicity : a study on rat liver and kidney cell membrane
Membrane damage is one of the important consequence of chromium, an environmental toxicant, to produce cytotoxicity. α-tocopherol, a membrane protectant can be used to reduce the chromium-induced membrane damage. In the present study, the impact of chromium in presence and absence of α-tocopherol was studied on plasma membrane of liver and kidney in male Wistar rats (80 - 100g body weight). Significant increase in membrane cholesterol level as well as significant decrease in membrane phospholipid level in chromium exposed ( 0.8 mg /100g body weight/d, i.p., for 4 weeks) animals suggest structural alteration of both liver and kidney plasma memebrane. The alkaline phosphatase, total ATPase and Na+-K+-ATPase activities of plasma membrane were significantly decreased in both liver and kidney after chromium treatment. However, α-tocopherol (30 mg / 100g diet) supplementation can restrict the changes in these membrane-bound enzyme activities. Thus, the usefulness of dietary supplementation of α-tocopherol to restrain the chromium-induced membrane damage is suggested.
作 者： Sankar Kumar Dey Prasunpriya Nayak Somenath Roy 作者单位： Department of Human Physiology with Community Health, Vidyasagar University, Midnapore - 721 102, West Bengal, India 刊 名： 环境科学学报(英文版) ISTIC SCI 英文刊名： JOURNAL OF ENVIRONMENTAL SCIENCES 年，卷(期)： 2003 15(3) 分类号： X171.5 关键词： chromium liver kidney membrane α-tocopherol