New insights into the immunology and evolution of HIV
Fewer than one million HIV infected individuals are currently receiving anti-retroviral therapy. Thelimitations of such treatment have underscored the need to develop more effective strategies to control thespread and pathogenesis of HIV. Typically, naturally occurring protective immune responses provide theparadigm for such development. It is now clear however that HIV can utilise the millieu of an activatedimmune system to its own replicative advantage. Mobilisation of the immune response, intended to thwartof HIV contributes to lack of immune control and the development of progressive disease in the majority ofinfected, untreated individuals. Further delineation of the intimate interactions between the HIV and theimmune system will be critical and recent advances in this direction are discussed.
作 者： JUSTIN STEBBING STEVE PATTERSON FRANCES GOTCH 作者单位： Department of Immunology, Division of Investigative Science, Faculty of Medicine, Imperial College of Science, Technology and Medicine, The Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, United Kingdom 刊 名： 细胞研究(英文版) ISTIC SCI 英文刊名： CELL RESEARCH 年，卷(期)： 2003 13(1) 分类号： Q2 关键词： HIV immune response CTL evolution vaccine