Improved Cardiac Contractility of Human Recombinant Growth Hormone on the Congestive Heart Failure of Pig
The enhanced cardiac contractility effect of human recombinant growth hormone (hr-GH) on the congestive heart failure (CHF) was studied on the pig. To build a pig model of congestive heart failure, a temporary artificial cardiac pacemaker was implanted in the pig's body and paced at 220 beats to 240 beats per minute for 1 week. After the model of congestive heart failure was successfully set up, the frequency of the pacemaker was changed to 150 beats to 180 beats per minute to maintain the CHF model stable. Pigs were divided into three groups: The hr-GH group in which 0.5 mg/kg per day of hr-GH was administrated intramuscularly for 15 days, the injection control group in which an equal amount of physiological saline was injected intramuscularly, and a normal control group. The left ventricular diastolic end pressure was (10.60±2.41 ) mmHg in the hr-GH group, but (19.00±3.81) mmHg in the saline control group (P＜0.01); Cardiac output was (1.86±0.13) L/min in the hr-GH group, but (1.56 ±0.18) L/min in the saline control group (P＜0.05); Peripheral min) -1 in the saline control group (P＜0.05); ± dp/dtmax was (2900 ±316.23) and (2280 ±286.36) in the hr-HG group and the saline control group respectively (P＜0.05). The results show that hr-GH enhances myocardial contractility of CHF, and the CHF model built by a temporary artificial cardiac pacemaker at a high rate of stimulation is reasonable and applicable.
作 者： Yang Ping HE Yu-quan Zeng Hong NI Jin-song Yun Qing-jun Huang Xiao-ping Li Shu-mei 作者单位： Yang Ping,HE Yu-quan,Zeng Hong,Yun Qing-jun,Huang Xiao-ping(Cadiovascular Department, China-Japan Union Hospital of Jilin University, Changchun 130021, P. R. China)NI Jin-song(Department of Pathdogy, School of Basic Medical Sciences of Jilin University, Changchun 130021, P. R. China)
Li Shu-mei(Cardiovascular Department, Second Hospital of Jilin University, Changchun 130041, P. R. China)
刊 名： 仿生工程学报（英文版） SCI 英文刊名： JOURNAL OF BIONICS ENGINEERING 年，卷(期)： 2005 2(2) 分类号： Q81 TB17 关键词： human recombinant growth hormone improved cardiac contractility experimental animal model temporary artificial cardiac pacemaker congestive heart failure