Study on the preparation and biodistribution of 99mTc-HMIBP
99mTc-HMIBP, a new bone-imaging agent, was prepared by the reduction of 99mTc-pertechnetate in the were more than 10 μg and 2.5 mg, respectively, the pH value was between 2 and 7, and the labeling reaction continued for 10 min, both labeling yield and radiochemical purity of 99mTc-HMIBP were more than 90%. The biodistribution in rats and bone scan in rabbits were also studied. The results showed that the bone uptake is up to 7.94%ID/g at 30 min after injection of 99mTc-HMIBP, bone-to-muscle and bone-to-blood uptake ratios were 20.89 and 16.89, respectively. The clear bone image was obtained at 120 min after injection of 99mTc-HMIBP and clearance in soft tissue was visible. All of the above-mentioned results suggested that 99mTc-HMIBP may be a potential bone-imaging agent.
作 者： GUO Xue-Hua LUO Shi-Neng WANG Hong-Yong ZHOU Lian XIE Min-Hao YE Wan-Zhong YANG Min WANG Yang 作者单位： GUO Xue-Hua,ZHOU Lian(School of Chemical and Material Engineering, Southern Yangtze University, Wuxi 214036, China;Jiangsu Institute of Nuclear Medicine, Wuxi 214063, China)LUO Shi-Neng(Jiangsu Institute of Nuclear Medicine, Wuxi 214063, China;School of Chemical and Material Engineering, Southern Yangtze University, Wuxi 214036, China)
WANG Hong-Yong,XIE Min-Hao,YE Wan-Zhong,YANG Min,WANG Yang(Jiangsu Institute of Nuclear Medicine, Wuxi 214063, China)
刊 名： 核技术(英文版) SCI 英文刊名： NUCLEAR SCIENCE AND TECHNIQUES 年，卷(期)： 2006 17(5) 分类号： O57 关键词： Bone-imaging agent 99mTc-labeled HMIBP Biodistribution