Crystal Structure and Antitumor Activity of Tri[2- [N-(4′-methyl-benzylsulfonyl)amino]ethyl]-amine
The crystal structure of the title compound (C27H38N4O7S3, Mr = 626.79) has been determined by single-crystal X-ray diffraction. The crystal is of triclinic, space group Pīwith a = 9.411(1), b = 11.645(2), c = 14.672(2) (A。), α = 91.80(1), β = 95.36(1), γ =104.56(1)o, V = 1547.0 (A。)3, Z = 2, Dc = 1.346 g/cm3, λ = 0.71073 (A。), μ(MoKα) = 0.289 mm－1 and F(000) = 664. The structure was refined to R = 0.0406 and wR = 0.1177 for 4103 observed reflections with I > 2σ(I). X-ray diffraction analysis reveals that the title compound is a practically distorted tetrahedron and each molecule contains one lattice H2O by hydrogen bond. The antitumor activity of the title compound against HL-60 human leukemia cells has also been studied by MTT method.
作 者： 台夕市 尹显洪 谭民裕 李一志 作者单位： 台夕市,谭民裕(College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China)尹显洪(College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China;Department of Chemistry, Guangxi University for Nationalities, Nanning 530006, China)
李一志(Coordination Chemistry Institute, State Key Laboratory of Coordination Chemistry, Nanjing University, Nanjing 210093, China)
刊 名： 结构化学 ISTIC SCI PKU 英文刊名： CHINESE JOURNAL OF STRUCTURAL CHEMISTRY 年，卷(期)： 2003 22(4) 分类号： O64 关键词： crystal structure distortion tetrahedron antitumor activity