One-pot Synthesis of Isoxazolines Using Soluble Polymer-supported Acrylates
An efficient and rapid parallel liquid-phase synthesis of isoxazolines has been reported.The one-pot three-component reaction of polyethylene glycol-supported acrylates, aldehydes and hydroxylamine hydrochloride in the presence of chloramine-T in methanol gave the corresponding PEG-supported isoxazolines, which can be cleaved from the support under mild condition to afford isoxazolines in good yields (＞80%) and high purities (＞86%).
作 者： Lan TAO Peng Fei ZHANG Yi Xin GU 作者单位： Department of Chemistry, Hangzhou Normal College, Hangzhou 310036 刊 名： 中国化学快报（英文版） ISTIC SCI 英文刊名： CHINESE CHEMICAL LETTERS 年，卷(期)： 2005 16(4) 分类号： 关键词： Isoxazolines,1,3-dipolar cycloaddition,soluble polymer,liquid-phase synthesis,polythylene glycol