Synthesis and Crystal Structure of (9S)-2-O-Benzoyl-9,11-[carbonylbis(oxy)]-9-deoxo-5-O-(β-D-desosaminyl)-12,21-anhydro-
The title compound (9S)-2'-O-benzoyl-9,11-[carbonylbis(oxy)]-9-deoxo-5-O-(-D-desosaminyl)-12,21-anhydro-9-hydroxyerythronolide A 1 was synthesized. The crystal structure of the acetone solvate of 1, C37H55NO11·C3H6O, was determined by single-crystal X-ray diffraction analysis. It belongs to monoclinic system, space group P21 with a = 14.4691(10), b = 8.2626(6), c = 17.5990(11) A, β = 94.167(1)°, V = 2098.4(2)A3, M,= 748, Z = 2, De= 1.184 g/cm3,μ = 0.087 mm-1, F(000) = 808, S = 1.026, R= 0.0542 and wR = 0.1322 for 3331 observed reflections (I > 2σ(Ⅰ)). In the solid state, molecules of 1 are linked into spirals along the b axis by O(25)-H(25)…O(29) intermolecular hydrogen bond.
作 者： WANG Yong-Tao CHEN Wei-Min HU Ai-Xi JIANG Ren-Wang CAO Gao SU Wen-Kui GUAN Dong 作者单位： WANG Yong-Tao(College of Chemistry and Chemical Engineering,Hunan University,Changsha 410082,China;Guangdong Provincial Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research,College of Pharmacy,Jinan University,Guangzhou 510632,China)CHEN Wei-Min,JIANG Ren-Wang,SU Wen-Kui,GUAN Dong(Guangdong Provincial Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research,College of Pharmacy,Jinan University,Guangzhou 510632,China)
HU Ai-Xi,CAO Gao(College of Chemistry and Chemical Engineering,Hunan University,Changsha 410082,China)
刊 名： 结构化学 ISTIC SCI PKU 英文刊名： CHINESE JOURNAL OF STRUCTURAL CHEMISTRY 年，卷(期)： 2009 28(2) 分类号： O6 关键词： crystal structure synthesis erythromycin derivatives