Investigation of protein-styrene oxide adducts as a molecularbiomarker of human exposed to styrene
Hemoglobin-styrene oxide adducts in blood has been studied as a molecular biomarker of worker exposed to styrene.Determination of protein-styrene oxide adducts in different biological samples with modified Raney-Ni procedure is described in this paper. The following biological samples have been investigated: fresh rat blood reacted with styrene oxide in vitro; rat blood reacted with styrene or styrene oxide in vivo; vein blood from workers exposed to styrene in two factories. The data showed that there was a good linear dose-response relationship between reacting dose of styrene oxide or styrene and amount of protein-styrene oxide adducts in both in vitro and in vivo experiments. For human samples, a dose-response relationship between protein adducts and styrene exposure can be found in glass fiber factory, but not in piano manufacture plant.
作 者： LIU Shu-fen FANG Qing-ming JIN Zu-liang Rappaport M S 作者单位： LIU Shu-fen,FANG Qing-ming,JIN Zu-liang(Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences,)Rappaport M S(UNC at Chapel Hill. NC.)
刊 名： 环境科学学报(英文版) ISTIC SCI 英文刊名： JOURNAL OF ENVIRONMENTAL SCIENCES 年，卷(期)： 2001 13(4) 分类号： X501.1 关键词：