A Brief Review on the Mechanisms of miRNA Regulation
MicroRNAs (miRNAs) are a class of short,endogenously-initiated non-coding RNAs that post-transcriptionally control gene expression via either translational repression or mRNA degradation.It is becoming evident that miRNAs are play-ing significant roles in regulatory mechanisms operating in various organisms,including developmental timing and host-pathogen interactions as well as cell differentiation,proliferation,apoptosis and tumorigenesis.Likewise,as a regu-latory element,miRNA itself is coordinatively modulated by multifarious effectors when carrying out basic functions,such as SNP,miRNA editing,methylation and circadian clock.This mini-review summarized the current understanding of in-teractions between miRNAs and their targets,including recent advancements in deciphering the regulatory mechanisms that control the biogenesis and functional-ity of miRNAs in various cellular processes.
作 者： Yimei Cai Xiaomin Yu Songnian Hu Jun Yu 作者单位： Key Laboratory of Genome Sciences and Information,Beijing Institute of Genomics,Chinese Academy of Sciences,Beijing 100029,China 刊 名： 基因组蛋白质组与生物信息学报（英文版） 英文刊名： GENOMICS、PROTEOMICS & BIOINFORMATICS 年，卷(期)： 2009 7(4) 分类号： Q5 关键词： non-coding RNA miRNA miRNA regulation targets