DNA sequence comparative analysis of the 3pter-p26 region of human genome
Most proterminal regions of human chromosomes are GC-rich and gene-rich. Chromosome 3p is an exception. Its proterminal region is GC-poor, and likely to lose heterozygosity, thus causing a number of fatal diseases. Except one gap left in the telomeric position, the proterminal region of human chromosome 3p has been completely sequenced. The detailed sequence analysis showed: (i) the GC content of this region was 38.5%, being the lowest among all the human proterminal regions; (ii) this region contained 20 known genes and 22 predicted genes, with an average gene size of 97.5 kb. The previously mapped gene Cntn3 was not found in this region, but instead located in the 74 Mb position of human chromosome 3p; (iii) the interspersed repeats of this region were more active than the average level of the whole human genome, especially (TA)n, the content of which was twice the genome average; (iv) this region had a conserved synteny extending from 104.1 Mb to 112.4 Mb on the mouse chromosome 6, which was 8% larger in size, not in accordance with the whole genome comparison, probably because the 3pter-p26 region was more likely to lose neocleitides and its mouse synteny had more active interspersed repeats.
作 者： LUO Chunqing LI Yan ZHANG Xiaowei ZHANG Yilin Zhang Haiqing CHEN Chong XU Zuyuan CUI Peng HU Songnian YANG Huanming DONG Wei 作者单位： LUO Chunqing,LI Yan,ZHANG Xiaowei,ZHANG Yilin,Zhang Haiqing,XU Zuyuan,YANG Huanming,DONG Wei(Institute of Genetic and Developmental Biology, Chinese Academy of Sciences, Beijing,100101,China;Beijing Genomics Institute, Chinese Academy of Sciences, Beijing,101300, China)CHEN Chong,CUI Peng,HU Songnian(Beijing Genomics Institute, Chinese Academy of Sciences, Beijing,101300, China)
刊 名： 中国科学C辑（英文版） SCI 英文刊名： SCIENCE IN CHINA SERIES C LIFE SCIENCES 年，卷(期)： 2005 48(1) 分类号： Q98 关键词： comparative analysis 3pter-p26 human genome