Neuron Protective Constituents from Rheum Nanum and Rheum Sublanceolatum
The neuron protective activity of the chemical constituents from Rheum nanum and Rheum sublanceolatum in vitro was investigated using cultured embryonic mouse cortical cells exposed to oxygen-glucose deprivation. The protective effect was quantitatively evaluated by measuring the lactate dehydrogenase release rate. Most of the compounds reduce the lactate dehydrogenase release rate, including emodin, chrysophanol-8-O-β-D-glucopyranoside, 6-hydroxymusizin-8-O-β-D-glucopyranoside, gnetin C, torachrysone-8-O-β-D-glucopyranoside, and maesopsin, and all possess potent neuron protective activity. Chrysophanol and aloe-emodin exhibit neuron protection only at low concentrations. Emodin-8-O-β-D-glucopyranoside protects the neuron cells at high concentration. Aloe-emodin-8-O-β-D- glucopyranoside is inactive.
作 者： XIANG Lan LEI Fan Xing Dongming WANG Wei Zheng Junhua 作者单位： XIANG Lan(Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China;School of Pharmacy, Shandong University, Ji'nan 250012, China)LEI Fan,Xing Dongming,WANG Wei(Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China)
Zheng Junhua(School of Pharmaceutical Science, Peking University, Beijing 100083, China)
刊 名： 清华大学学报（英文版） EI 英文刊名： TSINGHUA SCIENCE AND TECHNOLOGY 年，卷(期)： 2005 10(4) 分类号： Q2 关键词： Rheum nanum R. sublanceolatum chemical constituents neuron protective activity