Two Metabolites with DNA-Binding Affinity from the Mangrove Fungus Xylaria sp. (#2508) from the South China Sea Coast
A novel metabolite xylopyridine A (1), together with a known compound pyrocoll (2), was isolated from man-grove endophytic fungus Xylaria sp. (#2508) collected from the South China Sea coast. Their structures were estab-lished on the basis of spectroscopic analysis, especially 2D-NMR. Their affinities toward calf thymus (CT) DNA were studied by fluorescence quenching and spectrophotometric titration experiments. The results indicate that 1 showes strong DNA-binding affinity presumably via an intercalation mechanism, thus it is exploitable as strong DNA-binders.
作 者： XU Fang PANG Jiyan LU Bingtai WANG Jiajun ZHANG yi SHEZhigang VRIJMOED L LP GARETH JONES E B LIN Yongcheng 作者单位： XU Fang,PANG Jiyan,LU Bingtai,WANG Jiajun,ZHANG yi,SHEZhigang,LIN Yongcheng(School of Chemistry and Chemical Engineering,Sun Yat-Sen University,Guangzhou,Guangdong 510275,China)VRIJMOED L LP,GARETH JONES E B(Department of Biology and Chemistry,City University of Hong Kong,Hongkong 999077,China)
刊 名： 中国化学（英文版） SCI 英文刊名： CHINESE JOURNAL OF CHEMISTRY 年，卷(期)： 2009 27(2) 分类号： O6 关键词： fungus xylopyridine A isolation metabolite fluorescence CT DNA-binding