Synthesis and Anti-inflammatory Activity of a Novel Series of 9,10-Dihydro-4H,8h-chromeno[8,7-e][l,3]oxazin-4-one Deriva
Flavonoids exhibit a wide range of biological activities including anti-inflammatory activity,while some 1,3-benzoxazine derivatives show anti-inflammatory activity.In order to explore the novel anti-inflammatory agents,based on the principles of bioisosterism and hybridization,ten novel chromeno[8,7-e][l,3]oxazin-4-ones were synthesized and characterized with IR,~1H NMR,MS and elemental analyses.The anti-inflammatory activities of the target compounds were evaluated via the croton oil-induced ear oedema test in Swiss mice.According to screened results,some target compounds show potent anti-inflammatory activity.
作 者： LIU Xiao-ping WANG Ying LAN Hui-yu SONG Ai-hua TSIM Karl Wah-keung DONG Tina Ting-xia HU Chun 作者单位： LIU Xiao-ping,SONG Ai-hua,HU Chun(Department of Organic Chemistry,School of Pharmaceutical Engineering,Shenyang Pharmaceutical University,Shenyang 110016,P.R.China)WANG Ying,LAN Hui-yu(Tianjin Key Laboratory of Chemistry and Analysis of Chinese Materia Medica,Tianjin University of Traditional Chinese Medicine,Tianjin 300193,P.R.China)
TSIM Karl Wah-keung,DONG Tina Ting-xia(Department of Biology,The Hong Kong University of Science and Technology,Clear Water Bay,Kowloon,Hong Kong,P.R.China)
刊 名： 高等学校化学研究（英文版） ISTIC SCI 英文刊名： CHEMICAL RESEARCH IN CHINESE UNIVERSITIES 年，卷(期)： 2010 26(2) 分类号： O6 关键词： Anti-inflammatory activity Heterocycle Flavone Chromeno[8,7-e][1,3]oxazin-4-one