Palladium-catalyzed Substitution of Ketone or Aldehyde Bearing Aryl Triflates by Amines or Amides
Various aryl triflates, bearing ketone or aldehyde groups, were evaluated for palladium-mediated introduction of an amino group at the triflate position in the presence of various phosphine ligands. BINAP was best for secondary amines, MOP-type ligand for primary or small secondary amines and Xantphos for primary or cyclic secondary amides. No ligand was found effective for acyclic secondary amides.
作 者: TAO Xiaochun DAI Chunya CAO Xiongjie CAI Lisheng PIKE Victor W 作者单位: TAO Xiaochun,DAI Chunya,CAO Xiongjie(Laboratory of Organometallic Chemistry,East China University of Science and Technology,Shanghai 200237,China)CAI Lisheng,PIKE Victor W(Molecular Imaging Branch,National Institute of Mental Health,National Institutes of Health,Bethesda,MD 20892,USA)
刊 名: 中国化学(英文版) SCI 英文刊名: CHINESE JOURNAL OF CHEMISTRY 年,卷(期): 2009 27(2) 分类号: O6 关键词: atyl triflate substitution amine arnide palladium phosphine ligand