Comparative Analysis of Protein-Protein Interactions in Cancer-Associated Genes 25
Protein-protein interactions (PPIs) have been widely studied to understand the bi-ological processes or molecular functions associated with different disease systems like cancer. While focused studies on individual cancers have generated valuable in-formation, global and comparative analysis of datasets from different cancer types has not been done. In this work, we carried out bioinformatic analysis of PPIs corresponding to differentially expressed genes from microarrays of various tumor tissues (belonging to bladder, colon, kidney and thyroid cancers) and compared their associated biological processes and molecular functions (based on Gene On-tology terms). We identified a set of processes or functions that are common to all these cancers, as well as those that are specific to only one or partial cancer types. Similarly, protein interaction networks in nucleic acid metabolism were compared to identify the common/specific clusters of proteins across different cancer types. Our results provide a basis for further experimental investigations to study protein interaction networks associated with cancer. The methodology developed in this work can also be applied to study similar disease systems.
作 者： 作者单位： 刊 名： 基因组蛋白质组与生物信息学报（英文版） 英文刊名： GENOMICS、PROTEOMICS & BIOINFORMATICS 年，卷(期)： 2009 ""(1) 分类号： Q5 关键词： protein-protein interaction cancer-associated genes GO similarity analysis cancer bioinformatics