Effects of short-term IOP elevation on receptive field properties of cat LGN cells
To investigate the effects of short-term intraocular pressure (IOP) elevation on the receptive field properties of lateral geniculate nucleus (LGN) cells, responses of the LGN cells to annulus, disc and drifting gratings with high or low spatial frequencies have been recorded extracellularly in the cat with the retinal perfusion pressure kept stable (30mmHg). Our results indicated that the responses of the X and Y type LGN cells were significantly weakened during IOP elevation. And the responses varied with the different mechanisms of receptive fields. Specifically, while using annulus and disc as stimuli, the responses of Y cells were more tolerant than X cells to IOP elevation. The surround area of the receptive field was more sensitive to IOP elevation than the center. The mean responses during IOP elevation decreased more than the peak responses did. IOP elevation has more influence on the responses of X cells than on the response of Y cells to the drifting gratings with high spatial frequency. These results may reflect different degrees of ischemia on corresponding retinal structures caused by IOP elevation.
作 者： TAO Liming ZHANG Nan YE Xiang ZHOU Yifeng 作者单位： TAO Liming(Vision Research Laboratory, University of Science and Technology of China, Hefei 230027, China;Department of Ophthalmology, First Affiliated Hospital, Anhui Medical University, Hefei 230022, China)ZHANG Nan,YE Xiang(Vision Research Laboratory, University of Science and Technology of China, Hefei 230027,China)
ZHOU Yifeng(Vision Research Laboratory, University of Science and Technology of China, Hefei 230027,China;Visual Information Processing Laboratory, Institute of Biophysics,Chinese Academy of Sciences, Beijing 100101, China)
刊 名： 科学通报(英文版) SCI 英文刊名： CHINESE SCIENCE BULLETIN 年，卷(期)： 2004 49(12) 分类号： Q95 关键词： intraocular pressure (IOP) lateral geniculate nucleus (LGN) retina glaucoma cat