Biological effects of radioactive 9C-ion beams on cells
The distinguishing feature and current technique progress of tumor treatment with heavy-ion beams is introduced in the paper. Additional superiority to tumor treatment from a radioactive ion beam (RIB) is emphatically discussed. The experimental research of the radioactive 9C-ion beams aimed at tumor treatment at Heavy Ion Medical Accelerator in Chiba (HIMAC), National Institute of Radiological Sciences (NIRS), Japan is described in detail, including production of the beams, optimization of parameters,distribution of depth dose, survival effect of cell and com parison of RBE between 9C- and 12C-beams. Results show that under 40 mm thick Beryllium target and 10 mm thick aluminum degrader at full (5%) momentum acceptance, the production rate and purity of the produced 9C-beams are 9.07×10-6 and 82.88% respectively with the primary 12Cbeams of 430 MeV/u and 1.8×109 pps. A uniform irradiation field with homogeneity up to 89.6% inside central area 10 mm in diameter is obtained by using spot scanning. In this case, the dose rate at the entrance is 0.5 Gy/h. In survival experiment of cells, the average relative biological effectiveness (RBE) of 9C-beams is 5.28 and 2.93 for 12C-beams in the region around Bragg peak. The RBE of 9C-beams is 1.8 times higher than that of 12C-beams. It indicates that cell-killing efficiency of 9C-beams is stronger than that of 12C-beams.9C-beams are more efficacious for tumor treatment than 12C-beams.
作 者： Wei Zengquan LI Qiang A.KITAGAWA T.KANAI M.Kanazawa Y.Furusawa E.Urakabe Xie Hongmei Zhou Guangming 作者单位： Wei Zengquan,Xie Hongmei,Zhou Guangming(Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China)LI Qiang(Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China;National Institute of Radiological Sciences, Chiba 263-8555, Japan)
A.KITAGAWA,T.KANAI,M.Kanazawa,Y.Furusawa,E.Urakabe(National Institute of Radiological Sciences, Chiba 263-8555, Japan)
刊 名： 科学通报（英文版） SCI 英文刊名： CHINESE SCIENCE BULLETIN 年，卷(期)： 2005 50(11) 分类号： O6 关键词： radioactive ion beam parameter optimization cell survival effect RBE tumor treatment