Dendritic tellurides acting as antioxidants
We have described the synthesis of a series of poly(aryl ether) dendrimers with telluride in the core and oligo(ethylene oxide) chains at the periphery which act as glutathione peroxidase (GPx) mimics. These series of compounds were well characterized by 1H-NMR, 13C-NMR and ESI-MS. Using different ROOH (H2O2, cumene hydroperoxide) for testing the antioxidizing properties of these compounds, we have found that from generation 0 to 2, the activity of the dendritic GPx mimics first decreased and then increased. This can be explained on the basis of a greater steric hindrance, going from generation 0 to 1, and stronger binding interactions going from generation 1 to 2. In other words, there exists a balance between binding interactions and steric hindrance that may optimize the GPx activity.
作 者： XU Huaping WANG Yapei WANG Zhiqiang LIU Junqiu Mario Smet Wim Dehaen 作者单位： XU Huaping(Key Lab of Organic Optoelectronics and Molecular Engineering,Department of Chemistry,Tsinghua University,Beijing,100084,China;Key Lab for Supramolecular Structure and Materials,College of Chemistry,Jilin University,Changchun,130023,China)WANG Yapei,WANG Zhiqiang(Key Lab of Organic Optoelectronics and Molecular Engineering,Department of Chemistry,Tsinghua University,Beijing,100084,China)
LIU Junqiu(Key Lab for Supramolecular Structure and Materials,College of Chemistry,Jilin University,Changchun,130023,China)
Mario Smet,Wim Dehaen(Laboratory for Organic Synthesis,University of Leuven,Celestijnenlaan 200F,B-3001 Leuven,Belgium)
刊 名： 科学通报（英文版） SCI 英文刊名： CHINESE SCIENCE BULLETIN 年，卷(期)： 2006 51(19) 分类号： O6 关键词： dendritic telluride antioxidant glutathione peroxidase