Tin(Ⅱ) Chloride Dihydrate Catalyzed Groebke Condensation:An Efficient Protocol for the Synthesis of 3-Aminoimidazo[1,2-a
The ability of tin(Ⅱ) chloride dihydrate as a catalyst to promote the three-component condensation reaction from a diversity of aromatic aldehydes, 2-aminopyridines and isonitriles at room temperature is described. This method-ology affords a number of 3-aminoimidazo[1,2-aJpyridines in the presence of tin(Ⅱ) chloride dihydrate as a new and mild Lewis acid catalyst in the multi-component reaction in reasonable yields and short reaction time without any significant optimization of the reaction conditions.
作 者： SHAABANI Ahmad SOLEIMANI Ebrahim SARVARY Afshin REZAYAN Ali Hossein MALEKI Ali 作者单位： Department of Chemistry,Shahid Beheshti University,PO Box 19396-4716,Tehran,Iran 刊 名： 中国化学（英文版） SCI 英文刊名： CHINESE JOURNAL OF CHEMISTRY 年，卷(期)： 2009 27(2) 分类号： O6 关键词： tin(Ⅱ) chloride dihydrate,Lewis acid,isonitrile,3-aminoimidazo[1,2-α]pyridine